Cardiac Mechanics Simulator Tutorial

Exercise Set 1

II. Valve Pathologies

B. Mitral Stenosis

With mitral stenosis, the valve leaflets fail to open fully during ventricular diastole and hence cause an obstruction to ventricular filling. Instead of blood passing unimpeded from the LA to the LV, a significant pressure gradient is required to overcome this abnormal resistance to filling.

Vary the severity of mitral stenosis and make the following observations:

  1. How does mitral stenosis affect the shape of the P-V diagram?
  2. How does mitral stenosis affect cardiac output and left ventricular end-diastolic pressure?
  3. What is the impact of increasing heart rate on cardiac output?

Filling Pressure Threshold for Elastance/MAP effect is off. Was set to 50.0