Case Control Study
Step 1: Learning Objectives
- Apply the principles of case-control studies:
- Formulate research hypotheses
- Define population at risk for disease
- Define eligibility criteria for cases and controls
- Describe methods of accrual of cases and controls
- Define exposure
- Define exposure
- Employ steps in data analysis of case-control studies to analyze the data:
- Administrative procedures before start of the study
- Calculate disease odds ratio
- Calculate exposure odds ratio
- Explain your findings and discuss problems in data analysis:
- Explain how the size of the odds ratio influences your conclusions about the association between exposure and outcome
- Give your suggestions for carrying out this case-control study
- Discuss the importance of defining the underlying population for selection of cases and controls
- Discuss the importance of exchangeability of cases and controls
- Explain why exposure odds ratio is identical to the disease odds ratio
- Discuss the relationship between odds ratio and relative risk
- Discuss the value of statistical data analysis in reaching conclusions about causality of the exposure-outcome relationship