Exercises for Heart Mechanics

III B  -  Mitral Stenosis

With mitral stenosis, the valve leaflets fail
to open fully during ventricular diastole and hence cause an obstruction
to ventricular filling. Instead of blood passing unimpeded from the LA to
the LV, a significant pressure gradient is required to overcome this
abnormal resistance to filling.

Vary the severity of mitral stenosis and make the following observations:
1. How does mitral stenosis affect the shape of the P-V diagram?
2. How does mitral stenosis affect cardiac output and left ventricular
   end-diastolic pressure?
3. What is the impact of increasing heart rate
   on cardiac output?

Filling Pressure Threshold for Elastance/MAP effect is off. Was set to 50.0